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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

GASTRO-CYTOPROTECTIVE AND HEALING EFFECTS OF THE STEM BARKS AQUEOUS EXTRACT OF ANTHOCLEISTA SCHWEINFURTHII GILG (LOGANIACEAE) ON GASTRIC ULCERS

Christophe Mezui*, Frida Longo, Celine Nkenfou, Perfusion A. Amang, Ntsayo Fokou and Paul V. Tan

ABSTRACT

Anthocleista schweinfurthii is used in the traditional management of gastro-duodenal ulcers; this led us to evaluate the gastro-cytoprotective and healing effects of this plant. Anti-ulcer activity of the stem barks aqueous extract of Anthocleista schweinfurthii (EAS) was evaluated using five methods: HCl/ethanol; indomethacin - HCl/ethanol; Absolute ethanol; Pylorus-ligated (acute gastric lesions), and Acetic acid-induced chronic ulcers in rats. The parameters assessed were mucus production; gastric ulcer index; pH, acid concentration and volume of gastric contents. Sucralfate, cimetidine and ranitidine were used as the reference anti-ulcer drugs. In all cases, oral administration of EAS (250 and 500mg/kg), dose-dependently, prevented gastric lesion formation (p

Keywords: Gastric, ulcer, Cytoprotection, Anthocleista schweinfurthii, Loganiaceae.

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