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SYNTHESIS, REACTIONS OF 3-OXO-3-(3-OXO-3H-BENZO[f] CHROMEN-2-YL)-2-(2-PHENYLHYDRAZONO) PROPANAL, AND INVESTIGATION OF THEIR ANTITUMOR ACTIVITYDr Sobhi M. Gomhaa,* and Hassan M. Abdel-aziz b
a Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt. b Department of Chemistry, Faculty of Science, Bani Suef University, Bani Suef, Egypt.
ABSTRACT Heteroarylhydrazonalas were prepared from coupling of sodium salt of 2-(3-hydroxyacryloyl)-3H-benzo[f]chromen-3-one with various diazotized heterocyclic amines. Treatment of heteroarylhydrazonalas, with 2-cyanoacetamide, 3-oxo-3-phenylpropanenitrile, ethylcyanoactate, and -haloketones afforded the corresponding pyridazinone, pyridine, and pyrazole derivatives, respectively. The synthesized compounds were characterized on the basis of their elemental analysis and spectral data. All the newly synthesized compounds were evaluated for their antitumor activities against the human breast cancer cell line MCF-7 and the liver carcinoma cell line HEPG-2, and the results of some derivatives showed promising activity. Keywords: Coupling reaction, pyrazolotriazine, triazolotriazine, benzoimidazotriazine pyridazinone, and antitumor evaluation. [Download Article] [Download Certifiate] |