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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SYNTHESIS, REACTIONS OF 3-OXO-3-(3-OXO-3H-BENZO[f] CHROMEN-2-YL)-2-(2-PHENYLHYDRAZONO) PROPANAL, AND INVESTIGATION OF THEIR ANTITUMOR ACTIVITY

Dr Sobhi M. Gomha^a,* and Hassan M. Abdel-aziz ^b

^aDepartment of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt.

^bDepartment of Chemistry, Faculty of Science, Bani Suef University, Bani Suef, Egypt.

ABSTRACT

Heteroarylhydrazonalas were prepared from coupling of sodium salt of 2-(3-hydroxyacryloyl)-3H-benzo[f]chromen-3-one with various diazotized heterocyclic amines. Treatment of heteroarylhydrazonalas, with 2-cyanoacetamide, 3-oxo-3-phenylpropanenitrile, ethylcyanoactate, and -haloketones afforded the corresponding pyridazinone, pyridine, and pyrazole derivatives, respectively. The synthesized compounds were characterized on the basis of their elemental analysis and spectral data. All the newly synthesized compounds were evaluated for their antitumor activities against the human breast cancer cell line MCF-7 and the liver carcinoma cell line HEPG-2, and the results of some derivatives showed promising activity.

Keywords: Coupling reaction, pyrazolotriazine, triazolotriazine, benzoimidazotriazine pyridazinone, and antitumor evaluation.

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