Abstract

SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SOME NOVEL SUBSTITUTED 2-AMINO BENZOTHIAZOLE DERIVATIVES

D. Nooka Raju, D.V.R. Subhadra Devi, D. Grace Aghastina, K. Govinda Rao* and K. Sathish Kumar

ABSTRACT

The present study deals with synthesis of some novel substituted 2-amino benzothiazole and their spectral characterization by means of UV, IR and 1H NMR. The compounds were screened for analgesic activity. Results obtained established compounds J3 and J1 to have highly significant analgesic activity with reference to the standard aspirin and consequently further exploration of these benzothiazole derivatives should make these molecules accessible for widespread use as potent analgesic agents.

Keywords: Benzothiazole, aniline derivatives, Ammonium thiocyanate, Analgesic activity, Tail flick method.