![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OLMESARTAN MEDOXOMIL BY USING COPROCESSED EXCIPIENTS TECHIQUE
Iti Karia* and Dr. Ramesh B. Parmar
ABSTRACT In the present work, fast dissolving tablets of Olmesartan medoxomil were prepared using novel co-processed superdisintegrants consisting of crospovidone and croscarmellose sodium in different ratios (1:1, 1:2 and 1:3).Olmesartanmedoxomil (OLM) is an angiotensin II receptor blocker used for the treatment of hypertension. In present work an attempt was made to mask the metallic taste and enhance the solubility and dissolution rate of poorly soluble OLM by formulating it as inclusion complexesby kneading method with β-cyclodextrins (β-CDs) as complexing agentin 1:1 molar ratio. Effect of co-processed superdisintegrants on pre-formulation parameters, wetting time, disintegrating time, drug content and in-vitro release have been studied. Drug compatibility with excipients was checked by FTIR and DSC studies. The co-processing of the superdisintegrants was done by solvent evaporation. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. From the prepared inclusion complexes and co-processed excipients, fast dissolving tablets (FDTs) were formulated. In all the formulations, hardness test indicated good mechanical strength results ranging from 2.89 to 3.81 kg/cm2, friability is less than 1%indicated that tablets have good mechanical resistance. Wetting time is an important criteria for understanding the capacity of disintegrants to swell in presence of little amount of water were found to be in the range of 7.33 to 14.66 seconds. Disintegration time was found to be in the range of 8.33 to 20.00 seconds. Drug content was found to be in the range of 97.36 to 99.72 %. Among all the designed formulations, formulation CPI3 i.e.co-processed excipients having ratio CSS:CP (1:3) containing 5% w/w of co-processed superdisintegrants, was found to be promising and was displayed an in-vitro dispersion time of 8.33 seconds, which facilitates faster dispersion in mouth and wetting time of 7.33 seconds. From the present study, it can be concluded that dissolution rate of Olmesartan medoxomil could be enhanced by tablets containing co-processed superdisintegrants. Keywords: Olmesartan medoxomil, fast dissolving tablets, ?-cyclodextrin, Sodium Starch Glycolate, Crosscarmellose sodium, crospovidone, co-processed excipients. [Download Article] [Download Certifiate] |