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UV SPECTROPHOTOMETRIC ESTIMATION OF CARBAMAZEPINE IN BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD
Harshad J.Tambe* and Sugandha V. Mulgund
ABSTRACT The aim of present work was to develop an accurate, precise, reproducible and economical UV spectrophotometric Area Under Curve method for estimation of Carbamazepine. This Area Under Curve of UV spectrum between 275 to 295 nm was validated as per ICH guideline Q2 (R1). The method has followed linearity in the range of 2-12 μg/ml. The value of correlation coefficient was 0.999. Satisfactory values of Percent relative standard deviation for the intraday and inter-day precision indicated that method is precise. Results of the recovery studies (99.67% to 101.18%) showed accuracy of the method. LOD and LOQ were calculated as 0.2984 μg/ml and 0.9042 μg/ml, respectively. The developed method can be used for routine estimation of Carbamazepine in bulk and tablet dosage forms. Keywords: Carbamazepine, UV spectrophotometry, Area Under Curve, validation. [Download Article] [Download Certifiate] |