SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL CHALCONES AND PYRAZOLINE DERIVATIVES FROM 1-(3-CHLOROPHENYL) ETHANONE
G. Eswara Rao *, P. Srinivasa Babu, J Sambrajyam, N. Sresta, Md. Shaheem Sultana, R. Lakshmi Durga, K. Srikanth
ABSTRACT
Novel chalcones were synthesized by condensing 1-(3-chlorophenyl)
ethanone with aromatic aldehydes derivatives in dilute ethanolic
sodium hydroxide solution at room temperature according to Claisen -
Schmidt condensation. The synthesized chalcones compounds were
reacted with hydrazine sulphate upon cyclisation gives pyrazoline
derivatives. All these compounds were characterized by means of their
IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial
activity of these compounds was evaluated by the cup plate method.
Keywords: Chalcones, Pyrazole, Synthesis, Antimicrobial activity
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