DEVELOPMENT AND EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE
N. Raja*, S. Vijaykumar, R. Anantha kumar and C. Benedict jose
ABSTRACT
The present study deals with develop and evaluation a floating – pulsatile drug delivery system (FPDDS) of Metoprolol Succinate intended for chronopharmacotherapy of hypertension. The dry coated system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer, prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Metoprolol succinate is a cardio selective β1-adrenergic blocking agent used for mild to moderate hypertension. Generally in hypertension, the risk of getting heart attacks is just before the walking hours of the patient i.e, early in the morning and therefore the need of antihypertensive is typically felt during morning hours. Hence, the main objective of present work to formulate FPDDS of Metoprolol succinate in ordered to achieve drug release after pre-determined lag phase. Developed formulations evaluated for their physical characteristics, drug content, in-vitro drug release studies, Floating behavior. Results showed that a certain lag time before drug release due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer.
Keywords: Metoprolol Succinate, Pulsatile release, Floating pulsatile tablet, HPMC, Chronopharmacology and Anti Hypertensive.
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