WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

  • WJPPS: NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2024 Issue has been successfully launched on NOVEMBER 2024.

Abstract

DEVELOPMENT AND EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE

N. Raja*, S. Vijaykumar, R. Anantha kumar and C. Benedict jose

ABSTRACT

The present study deals with develop and evaluation a floating – pulsatile drug delivery system (FPDDS) of Metoprolol Succinate intended for chronopharmacotherapy of hypertension. The dry coated system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer, prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Metoprolol succinate is a cardio selective β1-adrenergic blocking agent used for mild to moderate hypertension. Generally in hypertension, the risk of getting heart attacks is just before the walking hours of the patient i.e, early in the morning and therefore the need of antihypertensive is typically felt during morning hours. Hence, the main objective of present work to formulate FPDDS of Metoprolol succinate in ordered to achieve drug release after pre-determined lag phase. Developed formulations evaluated for their physical characteristics, drug content, in-vitro drug release studies, Floating behavior. Results showed that a certain lag time before drug release due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer.

Keywords: Metoprolol Succinate, Pulsatile release, Floating pulsatile tablet, HPMC, Chronopharmacology and Anti Hypertensive.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More