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SYNTHESIS OF SOME PARACETAMOL CONTENING 2-OXOAZETIDINE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY*Vivek Gupta1, A. Pandurangan2
1Charak Institute of Pharmacy, Mandleshwar Dist. Khargone (M.P.) 2College of Pharmacy, MM University, Mullana, Ambala (Haryana)
ABSTRACT 4-acetamidophenoxyacetylhydrazide is synthesized from peracetamol which on reaction with various aldehyde gives Schiff bases. Schiff bases treated with chloroacetylchloride to produce2-oxo- azetidine derivatives. The entire synthesized compound characterized by physical and analytical data. Antimicrobial activity of synthesized compounds evaluated by cup-plate method. Keywords: Schiff bases, paracetamol, antimicrobial [Download Article] [Download Certifiate] |