SYNTHESIS OF SOME PARACETAMOL CONTENING 2-OXOAZETIDINE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY
*Vivek Gupta1, A. Pandurangan2
1Charak Institute of Pharmacy, Mandleshwar Dist. Khargone (M.P.)
2College of Pharmacy, MM University, Mullana, Ambala (Haryana)
ABSTRACT
4-acetamidophenoxyacetylhydrazide is synthesized from peracetamol
which on reaction with various aldehyde gives Schiff bases. Schiff
bases treated with chloroacetylchloride to produce2-oxo- azetidine
derivatives. The entire synthesized compound characterized by
physical and analytical data. Antimicrobial activity of synthesized
compounds evaluated by cup-plate method.
Keywords: Schiff bases, paracetamol, antimicrobial
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