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Abstract

SYNTHESIS OF SOME PARACETAMOL CONTENING 2-OXOAZETIDINE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY

*Vivek Gupta1, A. Pandurangan2

1Charak Institute of Pharmacy, Mandleshwar Dist. Khargone (M.P.)
2College of Pharmacy, MM University, Mullana, Ambala (Haryana)

ABSTRACT

4-acetamidophenoxyacetylhydrazide is synthesized from peracetamol which on reaction with various aldehyde gives Schiff bases. Schiff bases treated with chloroacetylchloride to produce2-oxo- azetidine derivatives. The entire synthesized compound characterized by physical and analytical data. Antimicrobial activity of synthesized compounds evaluated by cup-plate method.

Keywords: Schiff bases, paracetamol, antimicrobial


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