Abstract

REVIEW- ADVANCE TECHNIQUE IN OCULAR DRUG DELIVERY SYSTEM

Shravan Kumar Paswan*, Pritt Verma, Mahendra Singh Yadav, Debjit Bhowmik, Shyam Sundar Gupta, Lubna Azmi, Ila Shukla, Kalali Bhargava Ch.V.Rao

ABSTRACT

Eye diseases are commonly encountered in day to day life, which are cured or prevented through the conventionally used dosage forms like eye drops, ointments. Delivery to the internal parts of the eye still remains troublesome due to the anatomical and protective structure of the eye. Ophthalmic drug delivery is one of the most interesting and challenging problem facing the pharmaceutical companies in the market. The major problem associated with the conventional dosage forms is the bioavailability of drug. Poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in-situ-forming ophthalmic drug delivery systems prepared from polymers that exhibit reversible liquid-gel phase transition. To overcome these problems various types of dosage forms such as nanoparticles, liposomes and microemulsions have been developed. Controlled drug delivery systems offer many advantages over conventional dosage forms in terms of improving drug bioavailability, reducing toxicity and decreasing dosage frequency. Newer research in ophthalmic drug delivery systems is directed towards a amalgamation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug This review focuses on recent development in conventional and non-conventional ophthalmic dosage formulation and products used to achieve prolonged contact time of drugs with the cornea and increase their bioavailability and different technique and products for both mode of delivery.

Keywords: ophthalmic drugs, liposomes, nanoparticles, eye drops, ointments.