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TERFEZIA BOUDIERI AS SOURCES OF ANTITUMOR AND ANTIVIRAL AGENT
Dr. Amal A.I. Mekawey
ABSTRACT
Terfezia boudieri was used to study its ability to use as source of antitumor and antiviral agent. Six tumor cell lines and two viral cells (HSV-2 and VSV) tested for this investigation. Four extracts from T. boudieri were obtained by four solvents and SRB and MTT assays were occurred for measurement of Potential as antitumor and antiviral potency, respectively. Separation, purification and identification of most active compound were performed. Aqueous extract exhibited good results as antitumor agent whereas it exhibited IC50 against four cells lines HEP2, HCT116, MCF7 and CACO2 (3.6, 7.2, 8.4 and 9.2 [μm/ml], respectively) followed by chloroform extract (its IC50 against three cell lines) then acetone and methanol exhibited IC50 against only two cell lines as compared with 1 μm/ml of antitumor drug vinblastine. Also, four T. boudieri extracts showed moderate Keywords: Terfezia boudieri, antitumor, antiviral, SRP, MTT, HEPG2; HELA; MCF7; CACO; HCT116; HEP2, BHK, vinblastine, HSV-2; VSV and acyclovir, TLC. [Download Article] [Download Certifiate] |