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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

PREPARATION AND EVALUATION OF EFFERVESCENT TABLETS OF IBUPROFEN

*Jitul B Patel¹, B. N. Suhagia¹, Mehul N Patel¹, Tejas B Patel¹, Akash M Patel¹, Tushar R Patel¹

*¹Faculty of Pharmacy, Dharmsinh Desai University, Nadiad-387001, Gujarat, India.

ABSTRACT

Recently, fast-dissolving drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better compliance. Usually, elderly people experience difficulty in swallowing the tablet. Ibuprofen inhibits prostaglandin (PG) synthesis in peripheral tissue. The aim of this study was to formulate effervescent tablet with sufficient mechanical integrity and to achieve faster disintegration in the water. In preformulation study compatibility evaluation was performed which implies that drug acids bases and other excipient are compalible with each other different acid and base were based in combination to prepare tablet. Tablets were also prepared using different binding agent and evaluated for hardness, friability, solution time and pH of solution, effervescences. Tablet prepared using higher ratio of NaHCO3 and citric acid and pvp-K30 2% as binder show short solution time, higher pH and also has good hardness.

Keywords: Effervescent tablet, COX-1, COX-2, Ibuprofen.

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