Abstract

EVALUATION OF ANALGESIC ACTIVITY OF HIBISCUS TILIACEUS LINN WOOD

ABSTRACT

Aim and objectives: The purpose of this study was to evaluate and compare the analgesic activity of methanolic wood extract of Hibiscus tiliaceus Linn in experimental acute and chronic analgesic animal models. Material and method: Methanolic wood extract of Hibiscus tiliaceus Linn was prepared and tested for analgesic activity in albino mice (20-25 gm). The animals were randomly divided into five groups.( n= 6 in each group). Group I served as control, group II served as standard (Pentazocine 46.8 mg/kg body weight) and III, IV, V treated with extract orally 1 hour prior to experimentation. The analgesic activity of extracts was evaluated by using the Eddy’s hot plate method and acetic acid induced writing method. The percentage increase or decrease in reaction time (as index of analgesia) and change in number of writhing in test compared with standard treated and control treated groups Result: The percentage increase in reaction time at 90 minutes was 21.02 %, 79.96, and 158.05 % for extract at a dose of 100, 200 and 400 mg/kg body weight, respectively in acetic acid – induced writhing method (P < 0.01) when compared with control. The % inhibition of writhes or % protection were found to be 64.09 % 78.56 % and 81.45 % for extract at a dose 100, 200 and 400 mg/kg body weight, respectively in Eddy’s hot plate method (P < 0.01) when compared with control.

Keywords: Hibiscus tiliaceus Linn, analgesic activity, pentazocine, acetic acid.