Abstract

ANALGESIC, ANTI-INFLAMMATORY AND CNS ACTIVITIES OF THE METHANOLIC EXTRACT OF ARTOCURPUS HETEROPHYLLUS SEED

Shirajum Munira*, Mst. Luthfun Nesa, Md. Monirul Islam, Sharmin Sultana, Sarwar Hossain, Habiba Khanam, Humayun Kabir, Rubel Akanda and Dr. Mamunur Rashid

ABSTRACT

The present study was carried out to assess the analgesic, anti-inflammatory and CNS activities of the methanolic extract of Artocurpus heterophyllus seed. In statistical analysis, the dose at 200 mg/kg was found to exhibit (significant p=0.05) moderate analgesic activity (43.54%) against acetic acid induced method and showed higher analgesic activity (70%) against formalin induced pain in mice than standard diclofenac Na (68.67%). Anti-inflammatory activity of A.heterophyllus seed (ATS) was performed for using carrageenan induced hind paw edema model at the dose of 200 and 400 mg/kg body weight, P.O. The extract of A. heterophyllus seed (ATS) at both doses of (200 and 400 mg/kg) also showed sustained inhibition (40.86 and 56.96%) of paw edema at the 4th hour compared to indomethacin(71.01%). The CNS depressant activity was studied by open field and hole cross tests at the dose of 100 and 200 mg/kg and both doses showed significant (P=0.05) CNS depressant acivity at both 90 and 120 min in both method. The findings of the study suggested that A. heterophyllus seed have significant analgesic, anti-inflammatory and CNS effects conforming the traditional use of this plant.

Keywords: Analgesic, Anti-inflammatory, CNS activity, Artocurpus heterophyllus.