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COMPARATIVE EVALUATIONS BETWEEN CARBOPOL GEL AND PARAFFIN OINTMENT BASE FOR THE DEVELOPMENT OF TOPICAL SEMISOLID FORMULATION CONTAINING CLOTRIMAZOLE IP
Assistant Professor, Department of Pharmaceutics, Academy of Pharmaceutical Sciences, Pariyaram, Kerala, India.
ABSTRACT Selection of bases is very crucial during the development of topical semisolid preparations. In this investigation an attempt has been made to compare the performance of carbopol gel and paraffin base in the delivery of Clotrimazole IP. Developed formulations were subjected for evaluation for the drug content, pH, spreadebility, extrudability, viscosity,in vitro diffusion profile and in vitro antifungal activity. Stability profile of developed formulations was subjected for investigation. Results of investigation clearly proved the superiority of carbopol gel base for the development of topical semisolid formulation containing Clotrimazole. Keywords: Clotrimazole, in vitro diffusion, spreadebility, viscosity. [Download Article] [Download Certifiate] |