Abstract

THERMAL AND BIOCHEMICAL STUDIES ON SOME IMPORTANT SMUGGLED DRUGS IN SANA'A CITY, YEMEN

Maher Ali. Al.Maqtari*

ABSTRACT

Nothing is known about the smuggled drugs that affecting the antibiotic activity behavior of Cefadroxil, Amoxicillin, and Tetracycline in the Sana'a City. Studies conducted for the first time of these antibiotics behavior by using the nature sunlight and temperature. Cefadroxil and Amoxicillin have the same method of actions and effectiveness. While Tetracycline has other mode action but the inhibition zone of these compounds are smaller than the control. The antibacterial activities by using E.coli & Staphylococcus Sp. were tested against this isolation by disc diffusion method. It was found that the effect of the UV Sunlight and Temperature which they converts the antibiotic compounds to unknown different species and decomposition. It was noticed that the inhibition zone of the Tetracycline is significantly smaller than the Cefadroxil and Amoxicillin that are because of the degradation of Tetracycline by sunlight and temperature which were faster than Cefadroxil and Amoxicillin. We suggest that the storing of these kinds of antibiotics should be in a cool place and not exposed to sunlight and temperature range recommended for storage by the manufacturer.

Keywords: Antibiotics; Photolysis, ultraviolet radiation, Temperature, Smuggled drugs.