Abstract

DESIGN AND RELEASE CHARACTERISTIC OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS OF METOPROLOL SUCCINATE

Faizan Sayeed*, Gopal Garg and Abdul Sayeed

ABSTRACT

The sustained release system includes any drug delivery system that achieves slow and extended release of drug over an extended period of time. The present study was carried out to develop and evaluate the matrix tablets of Metoprolol succinate containing cellulose derivatives as release modifying polymer. Metoprolol succinate sustained release matrix tablets were prepared successfully by wet granulation using HPMC K100M and EC as polymers in different proportion, to retard the release and achieve required dissolution profile. The results of in-vitro drug release studies in simulated GI fluids showed that matrix tablets containing 1:1 ratio of HPMC K100M and EC (F-5) are able tocontrol the release of water-soluble Metoprolol succinate. Therefore it was concluded that HPMCK100M and EC in the ratio of 1:1 (F-5) is suitable for the formulating matrix system of Metoprolol succinate. The data generated from in-vitro studies showed, the drug release from matrices containing HPMCK100M and EC was based on diffusion and erosion. The physicochemical compatibility of the drug with polymers was established through IR spectroscopy. The study indicated that the drug have good compatibility with these polymers.

Keywords: Metoprolol succinate containing, IR spectroscopy.