![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF AGANOSMA CYMOSA AND ITS ANTIOXIDANT PROPERTY IN STREPTOZOTOCIN INDUCED DIABETES RATS*Sangeetha Jayaraman1, Abbulu Konde1, Sudhakar Muvvala2
1Department of Pharmacognosy, Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad, India – 500 014. 2Department of Biotechnology, Malla Reddy College of Pharmacy, Secunderabad, India – 500 014.
ABSTRACT The present study was carried out to illustrate the antidiabetic potential of ethanolic extract of Aganosma cymosa and to establish its antioxidant property. The antidiabetic activity of ethanolic extract of Aganosma cymosa in two different doses (200mg/kg and 400mg/kg, b.w.) was compared with standard Glibenclamide. The treatment for 28 days with standard and test doses showed significant (P<0.05) decrease in the blood glucose level. Test dose 2 (400mg/kg, b.w.) showed highly significant (P<0.0001) results when compared to diabetic control. The increased serum triglycerides, total cholesterol and Bilirubin levels were found decreased in standard and test dose treated groups, while the HDL level in the treated group was found elevated. The serum enzymes Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) were found significantly reduced when compared to diabetic control. The results were supported with the Histopathological studies of the pancreas, which showed remarkable changes in the restoration of islets of langerhans. The plant extract also exhibited a very good antioxidant activity by maintaining the levels of Catalase (CAT), Superoxide Dismutase (SOD), Reduced Glutathione (GSH), Glutathione peroxidase (GPx) and Lipid peroxidase (LPO). Keywords: Antidiabetic activity, in-vivo antioxidant activity, Aganosma cymosa, serum enzymes. [Download Article] [Download Certifiate] |