Abstract

FORMULATION AND CHARACTERIZATION OF PIOGLITAZONE HYDROCHLORIDE NANOPARTICLES

Appana Chowdary K*, Navya Lakshmi Raju Suravarapu and Swathi Meddala

ABSTRACT

The oral bioavailability of poorly water soluble drugs improved using Nanoparticles. The present research work is an attempt to develop and evaluate the Pioglitazone Hydrochloride Nanoparticles in order to improve it, s solubility and bioavailability of poorly water soluble drug. Nanoparticles were prepared by Polaxomer 188, Tween 80 and Poly Vinyl Pyrrolidine as stabilizers by Nanoprecpitation technique. The prepared Nanoparticles evaluated for Particle Size, Zeta potential, Fourier Transform Spectroscopy, Differential Scanning Calorimetry, Drug Content, Drug Entrapment Efficiency and In- Vitro Drug Release. The effect of different types of stabilizers and different types of polymers were studied to see their effect on morphological, physical and dissolution properties of Pioglitazone Hydrochloride was studied. The average particle size of Piogllitazone Hydrochloride was found to be in the range of 100-500nm. Differentail Scanning Calorimetry studies showed the crystallinity of precipitated Nanoparticles was decreased than the pure drug. Data of in-vitro drug release shown that the prepared Nanoparticles showed enhanced dissolution which may result in enhanced solubility. Among all the formulations the formulation prepared with Polaxomer 188 in 1% concentration as stabilizer and Eudragit L 100 as polymer in Acetone gave good results than others.

Keywords: Pioglitazone Hydrochloride, Nanoparticles, Precipitation Technique.