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FORMULATION AND EVALUATION OF PH-TRIGGERED IN SITU GEL FOR OCULAR DELIVERY OF NORFLOXACIN*Kinjal B. Rathod1, Mandev B. Patel2
1K.B. Raval College of Pharmacy, At Shertha, Gandhinagar, Pin- 382423, Gujarat, India. 2A-One College of Pharmacy, Enasan, Ahmedabad,Gujarat, India.
ABSTRACT The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an anti-bacterial agent- Norfloxacin, based on the concept of pH-triggered in situ gelation. Polyacrylic acid (Carbopol- 934) was used as the gelling agent in combination with HPMC K4 M which acted as a viscosity enhancing agent. The developed formulation was therapeutically efficacious, stable, non-irritant and provided sustained release of the drug over a period of 8-hours. The developed system is thus a viable alternative to conventional eye drops. Keywords: Norfloxacin, pH, Carbopol 934, In situ gel. [Download Article] [Download Certifiate] |