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Citation | 5450 | 3969 |
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DERIVATIVES OF 2-QUINOLONES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION
Dr. Sukhen Som*
ABSTRACT The present investigation deals with the synthesis and antibacterial evaluation of a series of 2-quinolone derivatives. The structural analysis and characterizations for the analogues were performed by their IR, 1HNMR and Mass spectral studies. The compounds were evaluated for antibacterial activity by cup-plate method. Compounds 3h, 3i and 3j showed good activity against the bacterial strains compared to the standard drug. In view of the antibacterial studies performed it can be concluded that these derivatives can be utilized and investigated further for their optimum pharmacodynamic and pharmacokinetic properties. Keywords: Acylation, m-toluidine, antibacterial activity. [Download Article] [Download Certifiate] |