Abstract

INVITRO EVALUATION OF ANTI-ARTHRITIC ACTIVITY IN DIFFERENT SOLVENT EXTRACTS FROM CUSCUTA REFLEXA.

Vennila V* and Anitha R

ABSTRACT

Objective: Cuscuta reflexa is a medicinal plant which is used for the treatment of arthritis in folklore medicine. The present study was aimed at the investigation of anti-arthritic activity of various solvent extracts of C. reflexa by invitro model. Materials and methods: The anti-arthritic activity of C. reflexa was done by invitro method of inhibition of protein denaturation. Different solvent extract of C. reflexa was subjected to invitro inhibition of protein denaturation in various concentrations : 100, 200, 400, 800 and 1000 μg/ml. Results: The present findings exhibited a concentration dependent inhibition of protein (egg albumin and bovine albumin) denaturation by the different solvent extracts of C. reflexa. The effect of diclofenac sodium was found to be less when compared with the methanolic extracts of C. reflexa (1000 μg/ml), and the protection percent increased with increase in the concentration of extracts of C. reflexa. Conclusion: From the present study it can be concluded that C. reflexa showed marked invitro antiarthritic activity against the denaturation of protein.

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