Abstract

EVALUATION AND ISOLATION OF NOVEL BINDING AGENT ALSTONIA SCHOLARIS IN THE FORMULATION OF TABLET

Abhijit Chanda*, Vikash B, Arijit Dey, Pankaj Gupta, Yuvraj P.K, Dr.Grace Rathnam

ABSTRACT

Plant gums and mucilage’s are being used due to their abundance in nature, safety and economy. So in the present study an attempt was made to know the efficacy of Alstonia scholaris gum as a binder in paracetamol tablets by comparing with starch. In majority of tablets and capsules binders are used as important additives and in the present study gum isolated from trunk of Alstonia scholaris was studied at different concentrations and conditions. The paracetamol granules were prepared with different concentration of gum as binder by wet granulation method and evaluated for moisture content, angle of repose, bulk and tapped densities. The tablets were evaluated for thickness, weight variation, hardness, friability, and disintegration time and in vitro release profiles. Studies showed that increase in binding concentration of Alstonia scholaris gum, increases the hardness, as well as the disintegration time, decreases the percentage friability and decreases percentage cumulative release. Results obtained indicated that Alstonia scholaris gum performed as good binder at lower percentage.

Keywords: Alstonia scholaris gum, Paracetamol, Starch binder.