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SYNTHESIS AND ANTI-INFLAMMATORY EVALUATION OF NEW 5- ARYLIDENE-3- METHYLSULPHONYL THIAZOLIDINE-2, 4-DIONES.
Rahul A. Waghmare* Manisha R. Bhosle, Lalit D. Khillare and Ramrao A. Mane
ABSTRACT A series of novel thiazolidine-2, 4-dione derivatives containing 3- methyl sulphonyl moiety were synthesized by following convenient synthetic protocols to investigate their potential anti-inflammatory activity. The chemical structures of the synthesized compounds were elucidated by spectral and elemental analyses. The evaluated compounds in the series exhibited significant anti-inflammatory activities when compared with reference drug indomethacin. Keywords: 5-Arylidene 2, 4-thiazolidinone dione, anti-inflammatory, mice paw edema. [Download Article] [Download Certifiate] |