Abstract

ANTIDIARRHOEAL ACTIVITY OF VARIOUS ROOT EXTRACTS OF GMELINA ARBOREA ROXB. IN EXPERIMENTALLY INDUCED DIARRHOEA IN MICE

*Sangram. K. Panda, Debajyoti. Das, Niraj K. Tripthathy

ABSTRACT

Diarrhoea has long been recognized as one of the most important health problems in the developing countries. Consumption of medicinal herbs is tremendously increasing over the past decade as alternative approach to improve the quality of life and maintain good health. Gmelina arborea root has been used traditionally for the treatment of anthelmintic, laxative, fever, piles, diarrhoea and urinary discharges. Therefore, the present study was undertaken to evaluate the antidiarrhoeal potential of G.arborea root extract in castor oil induced diarrhea model. For this Swiss albino mice of either sex were used. all the crude extracts of G.arborea root such as ethanol, ethyl acetate, nbutanol and petroleum ether were tested for antidiarrhoeal activity at 200 and 400 mg/kg body weight. Where as loperamide (3 mg/kg) were used as standard drugs and given orally. The ethanol & n-butanol extracts of root of G.arborea was found to be effective in a dose dependent manner against castor oil induced diarrhoea on experimental mice at the dose of 400 mg/kg body weight.

Keywords: Gmelina arborea root, antidiarrhoeal potential, laxative, fever, piles, diarrhoea and urinary discharges.