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SPECTRAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NEWLY SYNTHESIZED IMIDAZOLE DERIVATIVE
*Maruthamuthu, Rajakumar, Shameela Rajam, B.R. Venkatraman Christina Ruby
ABSTRACT Some novel imidazole were synthesized and evaluated for antimicrobial, anti-inflammatory and analgesic activity. The reaction of benzoicacid compounds with ammonium thiocyanate and bromine in glacial acetic acid yield 4-thiocyanatobenzoicacid.The title compounds were synthesized by treating 4-thiocyanatobenzoicacid with ethylene diamine and carbon-di-sulphide. Their structures were confirmed by IR, 1H-NMR and 13C-NMR. Antimicrobial activity against bacteria and fungi, anti-inflammatory activity and analgesic activity were studied for the synthesized compounds. Docking study was done and the compounds IM1 and IM2 were found to fit well with the target protein COX-1. Keywords: Imidazole, thiocyanation, ethylene diamine, docking study in biological activity. [Download Article] [Download Certifiate] |