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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SPECTRAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NEWLY SYNTHESIZED IMIDAZOLE DERIVATIVE

*Maruthamuthu, Rajakumar, Shameela Rajam, B.R. Venkatraman Christina Ruby
Stella, Bharathi Dileepan and Ranjith

ABSTRACT

Some novel imidazole were synthesized and evaluated for antimicrobial, anti-inflammatory and analgesic activity. The reaction of benzoicacid compounds with ammonium thiocyanate and bromine in glacial acetic acid yield 4-thiocyanatobenzoicacid.The title compounds were synthesized by treating 4-thiocyanatobenzoicacid with ethylene diamine and carbon-di-sulphide. Their structures were confirmed by IR, 1H-NMR and 13C-NMR. Antimicrobial activity against bacteria and fungi, anti-inflammatory activity and analgesic activity were studied for the synthesized compounds. Docking study was done and the compounds IM1 and IM2 were found to fit well with the target protein COX-1.

Keywords: Imidazole, thiocyanation, ethylene diamine, docking study in biological activity.

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