Abstract

TOXICOLOGICAL ASSESSMENT OF CYPERMETHRIN (25% EC) ON ACTIVITY LEVELS OF ASPARTATE AMINO TRANSFERASE (ASAT) AND ALANINE AMINO TRANSFERASE (ALAT) IN THE TISSUES OF CIRRHINUS MRIGALA (HAM.)

P. Neelima, J. Chandra Sekhara Rao, L. Cyril Arun Kumar and N. Gopala Rao*

ABSTRACT

Aminotransferases mobilize the amino acids into carbohydrate and lipid metabolism. ASAT and ALAT are two important enzymes mainly involved in the inter-conversion of important compounds such as pyruvate, oxaloacetate, α-ketoglutarate and aminoacids thus bringing the protein and carbohydrate metabolism on one hand and alanine, aspartic acid and glutamic acid on the other. A study was conducted to assess the activity levels enzymes Aspartate amino transferase and Alanine amino transferase in three tissues (gill, muscle and liver) of Cirrhinus mrigala (Ham.) exposed to sublethal concentrations (5, 10, 15 and 20% 96h LC50) for 2, 4, 6 and 8 days. The activities of ASAT and ALAT were increased in all the tissues with an increase in exposure period. The increased levels of amino transferases might be due to tissue damage under cypermethrin stress in C. mrigala. The dose as well as exposure period dependant alterations were observed.

Keywords: Cypermethrin, Cirrhinus mrigala, Enzyme activity, ASAT, ALAT, Gill, Muscle, Liver.