Abstract

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF TRICHOPUS ZEYLANICUS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

T.Sundar Rajan*, V.Velmurugan , S.Arunkumar

ABSTRACT

The aim of present study was externally induced oxidative stress and evaluates Antioxidant Activity and antidiabetic activity of ethanolic extract of Trichopus zeylanicus. Family Malvaceae leaves in streptozotocin induced diabetic rats. The ethanolic extract of Trichopus zeylanicus was studied for antidiabetic activity in streptozotocin induced diabetic rats by oral administration of extract 400mg/kg body weight for 15 days. The effect was compared with standard drug of Glibenclamide at oral dose of 0.5mg/kg. Determination of blood glucose level by GOD-POD kit method. The result shows the ethanolic extract of Trichopus zeylanicus leaves significantly lowered the blood glucose of hyperglycemic rats. From the toxicity study it was observed that ethanolic extract of Trichopus zeylanicus was nontoxic up to 5g/kg body weight and phytochemical study showed the presence of phytosterols, flavonoids and glycosides. It is concluded that Trichopus zeylanicus leaf extract has significant antidiabetic activity, which lowered the fasting blood glucose level in Streptozotocin induced diabetic rats.

Keywords: Anti diabetic activity, Trichopus zeylanicus, Streptozotocin, GOD-POD.