Abstract

PHARMACEUTICAL ASPECTS OF VARIOUS FLOATING DRUG DELIVERY SYSTEM

Pritesh Jha*, Vipul Prajapati, Himanshu Solanki, Girish Jani, Ushma Kotak

ABSTRACT

Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Floating drug delivery system provides local delivery to specific region like stomach and proximal small intestine and it‟s also shows better bioavailability and improved therapeutic activity and substantial benefits to patients. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems. The floating drug delivery systems are useful approach to avoid this variability with increase the retention time of the drugdelivery systems for more than 12 hours. Effervescent and noneffervescent are two class of floating drug delivery system and can formulate either in single unit dosage form or in multiple unit dosage form. The present review summarize the concept of floating drug delivery systems with the recent literature and current technology used in the development of floating drug delivery system as well as summarizes evaluation method and applications of various floating dosage forms.

Keywords: Gastrointestinal tract, Drug delivery system, Gastric retention time, Hydrodynamically balance system, floating drug delivery system.