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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

EVALUATION OF ANTIUROLITHIC POTENTIAL OF MORINGA OLIFERA IN EXPERIMENTAL ANIMAL MODEL

*Yogesh P. Talekar¹, Aswad B. Devi¹, Dr. Kishori G. Apte¹, Deepali Y. Talekar¹, Dr. Pradeep B. Parab¹

¹APT Research Foundation subsidiary of National Toxicology Centre, S.No.36/1/1, M.N.199 Pune - 411041, Maharashtra, India.

ABSTRACT

The effect of M.olifera root against ethylene glycol induced urolithiasis in Swiss albino mice is summarized in the present study. Urolithiasis was induced in mice by administering 0.75 % ethylene glycol in drinking water for 28 days and calcium oxalate crystals were confirmed by urine analysis and X rays. Then for next 28 days animals were dosed with drug and again urine analysis and X rays were done to confirm presence or absence of crystals. Oxalate, calcium, Phosphate, uric acid and proteins are important markers as well as citrate and magnesium are inhibitors which were tested for the confirmation of the stone. LDH and oxalate are the enzymes of liver and kidneys are having an important role in Urolithiasis were also estimated. After sacrificing the animals, histopathological studies showed significant data to confirm the efficacy of M.olifera roots as having anti-urolithic activity. The results of present study suggest usefulness of M.olifera in the treatment of kidney stone disease.

Keywords: Urolithiasis, Moringa olifera, Ethylene glycol, Calcium oxalate crystals.

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