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MATHEMATICAL MODELS FOR DRUG RELEASE CHARACTERIZATION: A REVIEW
Hina Kouser Shaikh*, R. V. Kshirsagar, S. G. Patil
ABSTRACT The objective of this review outlines the application of Mathematical models for study of release phenomenon of drug from dosage forms. Mathematically, it is easy to identify the designing of a particular Pharmaceutical system and it can be used to predict the effect of device design parameters on the release kinetic of the formulation. It is easier to obtain the quantitative analysis of data for dissolution release rate by using these models. The choice of selection of best model /appropriate model depends on the desired or required predictive ability and accuracy of the model. The underlying drug release mechanism can be elucidate which is not only of academic interest but a pre-requisite for an efficient improvement of the safety of the formulation and for effective trouble shouting during production. This review gives the idea about the current state of mathematical modeling of drug delivery including empirical/semi empirical and mechanistic release models. Keywords: Mathematical models, Release Kinetics, Applications. [Download Article] [Download Certifiate] |