![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
PHYSIOLOGICAL IMPACTS OF CHITOSAN SINGLY OR IN CONJUGATION WITH H2 RECEPTOR ANTAGONIST DRUG DURING NSAID THERAPY IN RATS
Nashwah I. Zaki, Lobna A. Hassanin, Amany Hegab, *Mehrevan Abd El- Moniem
ABSTRACT
Aspirin is a potent nonsteroidal anti-inflammatory drug that is used for the treatment of rheumatoid arthritis and related diseases as well as the prevention of cardiovascular thrombotic diseases. The aim of the present study is to explore how chitosan alleviates gastric inflammation induced by aspirin in rats and investigate whether chitosan singly or in-conjugated with Ranitidine could be more effective. Fifty four healthy female rat, were divided into nine groups. Aspirin by two doses (7 or 27 mg/ kg) combined administration with ranitidine (27 mg/kg) as reference drug or chitosan 2% or conjugate of chitosan with ranitidine by the same concentration via oral rout for ten days. Chitosan singly produced significant effects on gastric acidity, Keywords: Chitosan – Ranitidine- gastroprotective parameters-immunomodulatory cytokines-mucosal myeloperoxidase. [Download Article] [Download Certifiate] |