Abstract

LAWSONIA INERMIS AS NATURAL PRODUCT IN CHEMOPREVENTION OF HEPATOCELLULAR CARCINOMA

Abdel-hamid NM, Atef E. Abd El-Baky*, Mohamed O. and Thabet KM.

ABSTRACT

Somatostatin has a role in the progression and control of neoplastic disease. Hepatoprotective effect and anti-tumor action of Lawsonia inermis is the aim of this study. METHODS: Thirty two hepatocellular carcinoma (HCC) albino mice (20–25 g) were randomly divided into four groups (n=8). The first group doesn't treated and served as control. The second group was received octreotoid (0.1 mg/kg body weight). The third group was received ethanolic extract of Lawsonia inermis (200 mg/dl) mixed with drinking water. The Fourth group was received mixture of octreotoid and ethanolic extract of Lawsonia inermis. The treatment will began at 17th week till the last day of 18th week. All animals were sacrificed after 18 weeks. RESULTS: there was a significant decrease in mRNA expression of AFP and SSTR2 in treated groups with Lawsonia extract, octreotide or in combination when compared to control group. Also, hepatic content of GSH was significantly increased, while hepatic content of MDA significantly decreased. CONCLUSIONS: Flavonoids of Lawsonia inermis have both antioxidant and cytotoxic effect. The use of both Lawsonia extract and octreotide in treatment of HCC resulted in a good synergistic effect for combined therapy.

Keywords: Hepatoprotective, Lawsonia inermis, Octreotide, Synergistic, Flavonoids.