Abstract

ANALGESIC ACTIVITY OF EXTRACTS OF MALUS DOMESTICA (APPLE)

Riddhi Jagdish Patel* and Rachana Sarawade

ABSTRACT

Malus domestica (Apple) a traditional plant widely used since Iron Age and has multiple benefits. In the present study extracted & isolated pectin (MDP) from pulp and extracted quercetin (MDQ) was evaluated for analgesic action by using various animal models. MDP and MDQ extracted and identified by various phytochemical analysis method. The analgesic effect of MDP and MDQ was assessed by using differential pain models such as acetic acid induced writhing and formalin induced paw licking model. In acetic acid induced writhing, both MDP & MDQ showed inhibitory effect on writhing. In formalin induced paw licking model, MDP and MDQ inhibit both the phases, reduction in the licking time significantly increased in the late phase which indicates the action of drug more in peripheral pain pathway. The result of the present study demonstrates the marked analgesic effect of extracted compound from apple peels and pulp.

Keywords: analgesic, malus domestica, pectin, quercetin.