Abstract

DESIGN, OPTIMISATION AND IN-VITRO EVALUATION OF ATORVASTATIN CALCIUM FAST DISSOLVING TABLET BY USING SOLID DISPERSION TECHNIQUE

Sanket Kumar* Dr.Shiv Kr. Garg, Ajay Aseri

ABSTRACT

The aim of the present was to enhance the solubility and dissolution rate of a model drug, atorvastatin calcium (ATC) under the frame of improved bioavailability. Pre-formulation study and drug excipients compatibility study was done initially and the results obtained were directs the way and method of formulation. For this, development of fast dissolving tablet done as with or without Solid dispersion of ATC. Solid dispersion of ATC (40 mg) was prepared by using PEG 4000 as carrier in different ratio through solvent evaporation method. Then, best formulation of solid dispersed ATC (1:4) was evaluated and went for development and evaluation of fast dissolving tablet (FDT) by using Sodium starch glycolate, Crospovidone and Crosscarmellose sodium as superdisintegrants in different concentrations. Granules were evaluated for tests such as bulk density, tapped density, compressibility index and Hauser’s ratio and angle of repose before compression. Tablets were tested for weight variation, thickness, hardness, friability, disintegration time, swelling time and dissolution. Final tablet formulation was optimized on the basis of drug content analysis, disintegration study and in vitro dissolution study. The optimized formulation was found to be SFDT8. Final formulation of FDT containing solid dispersed ATC revealed that successfully improvement of solubility as well as dissolution of ATC in a very quick time. This study could be very much helpful for better bioavailability of poorly water soluble drug avoiding first pass metabolism. It can be concluded that the fast dissolving tablet was beneficial for delivering the drug which needs faster release to achieve the fast action.

Keywords: Fast dissolving tablets, Atorvastatin (ATC), Solid dispersion, PEG 4000, Dissolution studies.