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SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE AND PIOGLITAZONE BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD IN BULK AND CAPSULE DOSAGE FORMHemant K. Jain*, Suchit D. Mule1
1Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune -411041, Maharashtra, India.
ABSTRACT The present work describes first order derivative UV spectrophotometry for simultaneous estimation of Glimepiride (GLM) and Pioglitazone (PIO) in bulk drug and combined dosage form. Water: Acetonitrile (20:80) at pH 2.5 was used as a diluent. GLM and PIO were analysed at 268.73 nm and 226.72 nm, respectively using first order derivative Spectroscopy. This method was validated as per International Conference on Harmonization (ICH) guidelines. The values of correlation coefficient for GLM and PIO were 0.9996 and 0.9991, respectively. The percent recovery for GLM and PIO was in the range of 98.6-101.2% and 98.85-100.7%, respectively. Precision and result of assay of formulation were satisfactory. Statistical analyses for the results suggest that the method can be applied for the routine estimation of GLM and PIO in capsule dosage form. Keywords: Glimepiride, Pioglitazone, Derivative Spectrophotometry, Simultaneous Estimation, Validation. [Download Article] [Download Certifiate] |
