Abstract

EXPLORING PROTECTIVE ROLE OF WATER EXTRACT OF SPIRULINA PLATENSIS ON DOCETAXEL-INDUCED LIPID PEROXIDATION USING NITRIC OXIDE AS MODEL MARKER

Supratim Ray*

ABSTRACT

Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the antiperoxidative potential of water extract of Spirulina platensis on docetaxel-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the nitric oxide (NO) content of liver tissue homogenates as marker of lipid peroxidation. The study reveals the lipid peroxidation induction capacity of docetaxel and the antiperoxidative potential of water extract of Spirulina platensis on docetaxel-induced lipid peroxidation.

Keywords: Docetaxel, lipid peroxidation, Spirulina platensis, nitric oxide.