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SYNTHESIS OF SOME NEW 1,2,3-TRIAZOLE DERIVATIVES OF INDOLE WITH POTENTIAL ANTIMICROBIAL ACTIVITY
B. Satyanarayana Reddy*, B. Srinivasa Reddy, Chowdoji Rao and MCS. Subha
ABSTRACT Seven novel [1-(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1H-indol-3-yl]-acetic acid ethyl ester and their derivatives (5a-g) have been synthesized through cyclization from the intermediate, (1-prop-2-ynyl-1H-indol-3-yl)-acetic acid ethyl ester (3) by using (1H-indol-3-yl)-acetic acid ethyl ester (1) and 3-bromo-propyne (2) as raw materials. The chemical structures of these compounds have been established by IR, 1H, 13C-NMR, Mass spectral data and elemental analysis. The newly synthesized compounds were used to find their ability towards antibacterial activity. Keywords: Seven novel, newly synthesized compounds, antibacterial activity. [Download Article] [Download Certifiate] |