Abstract

EVALUATION OF ANALGESIC ACTIVITIES OF AQUEOUS EXTRACT OF MEDICINAL PLANT KIGELIA AFRICANA (LAM.) BENTH.,

R.Bhramaramba*, Pydi.Chinna Raja, P.Varun, P.A.Sravanth and S.Giridhar

ABSTRACT

The Kigelia africana (Lam.) Benth., has been widely used for its reported biological activity in indigenous system of medicine. The present investigation was carried out to found the analgesic effect of fruits aqueous extracts of Kigelia africana (Lam.) Benth., in experimental animal models of pain. The analgesic activity was evaluated by acetic acid induced writhing method in albino mice and by tail immersion method in albino mice respectively. The percentage inhibition of writhing showed by aqueous extracts of Kigelia africana (Lam.) Benth., in doses of 100 mg/kg and 200 mg/kg was 48.69 and 55.15 respectively. In the tail immersion model, the aqueous extracts of Kigelia africana (Lam.) Benth., in the above doses increased the pain threshold significantly after 30 min, 60 min, 90 min, 120 min and 180min of administration. The aqueous extracts of Kigelia africana (Lam.) Benth., in different doses (100 and 200mg/kg, oral route) exhibited dose dependent and significant analgesic activity in both models of pain.

Keywords: Analgesic, Kigelia, Acetic induced writhing and tail immersion method.