Abstract

FABRICATION AND CHARACTERIZATION OF MECLIZINE HYDROCHLORIDE BIOADHESIVE PATCH

Siddhesh Javery* and Abha Doshi

ABSTRACT

Buccal delivery of drugs provides an attractive alternate to other conventional methods of systemic drug administration, since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs. In the present work, the main aim was to develop, evaluate and optimize mucoadhesive buccal patches of meclizine hydrochloride using polymers HPMC 15 cps as the mucoadhesive polymer and PVP K-30 as hydrophilic polymer. The main objective of this study is to reduce the dose, dosing frequency and bypassing first pass metabolism. From preformulation studies, there was no chemical interaction between meclizine hydrochloride and excipients. The patches were evaluated for thickness, uniformity of weight, percentage moisture absorption, mucoadhesion time, surface pH, drug content etc. All the evaluation parameters were found to be within acceptable limits. The patches showed sustained release for a period of 2 h thereby achieving therapeutic efficacy and good patient compliance. Optimization of formula was done by selecting 23 full factorial designs. It was employed to study the effect of independent variables of HPMC 15 cps (X1), PVP K-30 (X2) and Glycerine (X3), which significantly influenced the dependent variables % cumulative release (drug permeation) and mucoadhesive strength. The optimized patches were found to be stable when exposed to accelerated stability conditions.

Keywords: Buccal patches, meclizine hydrochloride, HPMC 15 cps, PVP K-30, Optimization.