Abstract

EFFICIENCY OF RICINUS COMMUNIS EXTRACT IN MODIFYING CYCLOPHOSPHAMIDE INDUCED CLASTOGENICITY IN MICE BONE MARROW CELLS

P.Jytothirmaye* and Dr. Raju lingumpelly

ABSTRACT

Genotoxicity describes a deleterious action on a cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumors. This includes both certain chemical compounds and certain types of radiation. Typical genotoxins like aromatic amines are believed to cause mutations because they are nucleophilic and form strong covalent bonds with DNA resulting with the formation of Aromatic Amine-DNA Adducts, preventing accurate replication. Genotoxins affecting sperm and eggs can pass genetic changes down to descendants who have never been exposed to the genotoxin. All known human toxicity derives from one of three types of genotoxicity i.e. Gene mutations, stable chromosomal aberrations or changes in chromosomal number (Environmental Health Perspect, 1996).The present study will be undertaken with an objective of Evaluating the Antimutagenic activity of Extract Ricinus communis in mice using bone marrow micronucleus test and assess the genotoxicity potential of Extract Ricinus communis using Micronuclues test with Cyclophosphamide using Bone Marrow Cells in Swiss Albino Mice.

Keywords: Genotoxicity, micronucleus test, Cyclophosphamide, Ricinus communis.