Abstract

FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF TELMISARTAN

Sailaja Gunnam*, Sabitha Saini, Madhuri.T

ABSTRACT

The aim of this study was to improve the dissolution rate of the poorly soluble drug Telmisartan by delivering the drug as a liquisolid compact. Liquisolid compacts were prepared using Polyethylene glycol 400 as non-volatile solvent, Avicel PH102 as carrier, and Aerosil 200 as the coating material. Telmisartan was formulated as liquisolid compacts in different concentrations of drug in non-volatile vehicle (15%w/w, 20% w/w, 40% w/w, 60%w/w and 80% w/w) with different excipient ratios (R) (5:1, 10:1, and 20:1) were studied and the release behavior was compared with that of the marketed tablet (Telmikind-40). The prepared liquisolid powders were evaluated for the flow properties like angle of repose, Carr’s compressibility index and Hausner’s ratio. The formulated liquisolid compacts were mixed with a superdisintegrant (sodium starch glycolate) and compressed in to tablets (F1-F15) and were evaluated for various post compression parameters such as hardness, friability, content uniformity, disintegration time and dissolution test. The formulated liquisolid compacts exhibited acceptable flowability, compressibility and markedly given improved percentage of drug release (87.9 %). Among all of the formulated tablets (F1-F15), telmisartan F-9 formulation exhibited enhanced dissolution rates when compared to the directly compressed telmisartan formulation (Telmikind-40) owing to increased wetting properties and enhanced surface exposure of drug moiety for dissolution. FTIR study revealed that there is no drug excipient interaction. From this study it was concluded that the liquisolid technique is an effective approach to enhance the dissolution rate of telmisartan.

Keywords: Telmisartan, Liquisolid compact, Telmikind-40.