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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR TRAMADOL HYDROCHLORIDE

Smita Nayak*, Varshakumari Singh and Vaidhun Bhaskar

ABSTRACT

The objective of the study is to develop simple, precise and accurate UV spectrophotometric method for analysis of Tramadol hydrochloride (TH) from bulk drug as well as formulation. The drug was dissolved in a suitable solvent and its absorption pattern over the wavelength of 200-400 nm was studied. The drug exhibited absorption maxima at 272 nm. The calibration curve was plotted and found to obey Beer-Lamberts law in the concentration range of 25-150 μg/ml with regression coefficient of 0.996. The method was successfully validated as per ICH guidelines. The developed method was found to be suitable for routine quality control analysis of Tramadol hydrochloride From bulk as well as formulation without interference of excipients.

Keywords: Tramadol hydrochloride ? linearity ? precision ? accuracy ? robustness? ruggedness.

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