Abstract

FORMULATION AND IN VITRO EVALUATION OF CATECHIN MUCOADHESIVE BUCCAL PATCHES

Sankar. S.*, Chitra. K and Saravanan. V. S.

ABSTRACT

The aim of the present work is to investigate the formulation of catechin buccal patches for controlled release. The half life of catechin is 3 hrs. Catechin has many good pharmacological action which required prolonged drug release and to avoid degradation of drug in GIT. The buccal patches were prepared by solvent casting method using chitosan. The patches were found to be smooth in appearance, uniform in thickness, weight uniformity, drug content, swelling index, folding endurance, surface pH and in vitro diffusion study using Franz diffusion cell. The optimized patch of 2% chitosan and Marrigold extract exhibit in vitro release of 54% through cellophane membrane. The patches were stable at a temperature range of 2-300C.

Keywords: catechin, buccal patch, diffusion, in vitro.