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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ANTIEPILEPTIC POTENTIAL OF BARK AND LEAVES OF ARTOCARPUS HETEROPHYLLUS LAM. (JACKFRUIT) AGAINST SEIZURES INDUCED BY MES AND STRYCHNINE NITRATE IN EXPERIMENTAL MICE

Om Prakash¹*, Jyoti², Amit Kumar¹, Pavan kumar¹, Rajiv Gupta³

¹Department of Pharmacy, Sagar Institute of Technology & Management, Barabanki, U.P. - 225 001, India.

²Advance Institute of Pharmaceutical Education & Research, Kanpur, U.P. -209217, India.

³Department of Pharmacy, Babu Banarasi Das National Institute of Technology & Management, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, U.P. -227 105, India.

ABSTRACT

The anticonvulsant activity of aqueous and methanolic extracts of bark and leaves of Artocarpus heterophyllus Lam. was evaluated in Swiss albino mice by using Maximal electroshock (MES) and Strychnine nitrate induced convulsions models at two dose levels of 100 mg/kg and 82.5 mg/kg body weight. The methanol extract of the bark and leaves of Artocarpus heterophyllus Lam. offered protection to mice against maximal electroshock induced seizure and also delayed the onset of Strychnine nitrate induced convulsions models as compared to aqueous extract. It could be concluded that the methanolic extracts of Artocarpus heterophyllus Lam. leaves, possesses potent anticonvulsant potential. The analysis revealed only minor differences in the anticonvulsant activity as compared with bark of Artocarpus heterophyllus Lam. The methanol extracts of leaves of Artocarpus heterophyllus Lam. were found to be more potent, while bark extracts were found to be less potent with regards to antiepileptic activity in comparison with the reference standard drug Diazepam (5mg/kg), p.o. The results are quite encouraging for further investigations regarding isolation and mechanism of action in future.

Keywords: Anticonvulsant activity, Artocarpus heterophyllus Lam., Maximal electroshock, Strychnine nitrate.

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