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ANTIEPILEPTIC POTENTIAL OF BARK AND LEAVES OF ARTOCARPUS HETEROPHYLLUS LAM. (JACKFRUIT) AGAINST SEIZURES INDUCED BY MES AND STRYCHNINE NITRATE IN EXPERIMENTAL MICEOm Prakash1*, Jyoti2, Amit Kumar1, Pavan kumar1, Rajiv Gupta3
1Department of Pharmacy, Sagar Institute of Technology & Management, Barabanki, U.P. - 225 001, India. 2Advance Institute of Pharmaceutical Education & Research, Kanpur, U.P. -209217, India. 3Department of Pharmacy, Babu Banarasi Das National Institute of Technology & Management, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, U.P. -227 105, India.
ABSTRACT The anticonvulsant activity of aqueous and methanolic extracts of bark and leaves of Artocarpus heterophyllus Lam. was evaluated in Swiss albino mice by using Maximal electroshock (MES) and Strychnine nitrate induced convulsions models at two dose levels of 100 mg/kg and 82.5 mg/kg body weight. The methanol extract of the bark and leaves of Artocarpus heterophyllus Lam. offered protection to mice against maximal electroshock induced seizure and also delayed the onset of Strychnine nitrate induced convulsions models as compared to aqueous extract. It could be concluded that the methanolic extracts of Artocarpus heterophyllus Lam. leaves, possesses potent anticonvulsant potential. The analysis revealed only minor differences in the anticonvulsant activity as compared with bark of Artocarpus heterophyllus Lam. The methanol extracts of leaves of Artocarpus heterophyllus Lam. were found to be more potent, while bark extracts were found to be less potent with regards to antiepileptic activity in comparison with the reference standard drug Diazepam (5mg/kg), p.o. The results are quite encouraging for further investigations regarding isolation and mechanism of action in future. Keywords: Anticonvulsant activity, Artocarpus heterophyllus Lam., Maximal electroshock, Strychnine nitrate. [Download Article] [Download Certifiate] |