Abstract

FORMULATION AND EVALUATION OF ATENOLOL AND HYDROCHLOROTHIAZIDE BILAYERED TABLET

Marathwada Mitra Mandal’s, College of Pharmacy, Thergaon (Kalewadi), Pune-33. India.

ABSTRACT

The aim of present study is to develop a bilayered tablet for management of Hypertension using Hydrochlorothiazide and Atenolol. The bilayered tablets gives biphasic drug release like loading dose of HCTZ and maintenance dose of Atenolol. The bilayered tablets are prepared using croscarmellose sodium as superdisintigrant for immediate released layer and different viscosity grades of hydrophilic polymers for sustained released layer, prepared tablets are evaluated for their physic-chemical properties. In this study, formulation (A6) made up from 10% CCS, and formulation (B6) made up from intragranulation techniques and 30mg blend of polymers releases the total drug content at the end of the 60 minutes and 12 hrs respectively. The release data obtained from the dissolution study of bilayered tablets are analyzed with respect to zero order, first order, Higuchi, Korsmeyer-Peppas models and release kinetic is fitted to Korsmeyer-peppas equation. The mechanism of drug release was regarded as anomalous diffusion of drug from matrix. The optimized formulation fulfilled many requirements such as easy to fabricate and high patient compliance.

Keywords: Bilayered tablets, Hydrochlorothiazide, Atenolol, CCS, Hydrophilic polymers.