Abstract

APPLICATION OF RHEOLOGICAL SYNERGISM BETWEEN HYDROPHILIC GUMS IN THE DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS

Sunil V. Garad*, Chandraprabhu M. Jangme and Nitin D. Somnathe

ABSTRACT

The objective of the present study was to design oral sustained drug delivery system using rheological synergism in between karaya gum and xanthan gum. Metoprolol succinate was chosen as model drug. Nine batches of matrix tablets were prepared by using karaya gum and xanthan gum in concentration of 15%, 20% and 25%. The gums was used in single and in combination with the ratio of 2:8 (karaya gum: xanthan gum) that gives rheological synergism. Matrix tablets were prepared by wet granulation method and were evaluated for different parameters such as weight variation, content uniformity, friability, hardness, thickness, in vitro dissolution study, stereo photography and swelling index. Among the formulations studied F2, F6 and F8 showed good release of drug for 12 hrs, which was 97.24%, 97.65% and 98.19% respectively. The optimized batches showed stability with respect to release pattern for six months at 400C and 75%RH. The kinetic treatment showed that the formulations follow zero order with release exponent (n) 0.7922, 0.7381 and 0.7656. It was concluded that gums possess substantial matrix forming properties with sustaining the release of drug.

Keywords: Sustained release, Karaya gum, Xanthan gum, Metoprolol succinate.