Abstract

ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF VORICONAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW

Belide.Pavani Venkat*

ABSTRACT

Voriconazole which is chemically (2R, 3S)-2-(2,4-difluorophenyl)-3-(5- fluoro pyrimi din-4-yl) -1- (1,2,4-triazol-1-yl) butan- 2-ol. Voriconazole is a triazole antifungal agent. The primary mode of action of voriconazole is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity of voriconazole. Voriconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems. Invasive aspergillosis and serious fungal infections due to Fusarium spp. and Scedosporium apiospermum. Literature survey reveals that Voriconazole is estimated individually by UV spectrometry, RP-HPLC, HPLC-UV, RP-UPLC, LC/MS/MS, HPTLC and stability indicating UPLC.

Keywords: Voriconazole, UV Spectroscopy RP-HPLC HPLC-UV RP-UPLC LC-MS/MS HPTLC and Stability indicating UPLC.