Abstract

RECENT ADVANCEMENT IN FLOATING DRUG DELIVERY SYSTEM AND CURRENT APPROACHES

Sharma Pooja*, Garg Shiv and Mann Monika

ABSTRACT

The purpose of writing this review on FDDS was to compile the recent literature with special focus on the approaches, principal mechanism and recent advancement of floatation to achieve gastric retension. FDDS are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma levels as well as improving bioavailability. FDDS have bulk density less than gastric fluids that have sufficient buoyancy to float over the gastric contents and remain in the stomach for longer duration of time without affecting gastric emptying rate and thereby improve the bioavailability of drugs. Several approaches are currently utilized in the prolongation of GRT including floating drug delivery system, swelling and expanding systems, polymeric bioadhesive systems, high density systems, modified shape systems and other delayed gastric emptying devices. Floating dosage forms are emerging as promising dosage forms which can be prepared as tablets, capsule by adding suitable ingredients as well as by gas generating agents. Various components like hydrocolloids, inert fatty materials and buoyancy increasing agents can be used to formulate floating dosage forms. Various categories like antacids, antidiabetic, antifungal and anticancer drugs are formulated into FDDS. FDDS provides local delivery to specific region like stomach and proximal part of the small intestine and it also shows better bioavailability and improved therapeutic activity and substantial benefits to patients. The recent development of FDDS such as physiological and formulation variables affecting gastric retension approaches to design single unit and multiple unit floating systems and their classification such as effervescent and non effervescent systems and formulation aspects are covered in detail. This review.

Keywords: Floating drug delivery system, approaches, application, marketed products, mechanism, recent advancements, patents, manufacturing techniques, characterization.