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RECENT ADVANCES IN ANALYTICAL METHODS FOR DETERMINATION OF CREATININE
Gaaminepreet Singh* and Pawan Krishan
ABSTRACT
According to the United States National Chronic Kidney Disease Fact Sheet, 2014 more than 20 million people may have chronic kidney disease. Numerous studies have reported a strong association between the various stages of chronic kidney diseases and glomerular filtration rate (gfr). Although there have been a recent increase in published reports on novel endogenous and exogenous diagnostic markers for glomerular filtration rate, creatinine determination is still widely used worldwide as an efficient endogenous biomarker for assessment of kidney function in patients with chronic kidney disease as evidenced by development of modified equations of creatinine clearance for determination of glomerular filtration rate in kidney pateints. Various analytical methods for determination of accurate concentration of creatinine in serum and urine have been developed. Due to the poor Keywords: gfr (glomerular filtration rate), GC-MS (gas chromatography mass spectrometry), LC-MS (liquid chromatography mass spectrometry), SRM (standard reference material), CKD (chronic kidney disease). [Download Article] [Download Certifiate] |