Abstract

ANTICANCER ENDOPHYTIC METABOLITES OF THE MEDICINAL PLANT CENTAUREA STOEBE

Randa Abdou* and Mohamed I.S. Abdelhady

ABSTRACT

Natural products from endophytes are considered promising sources of new antimicrobial agents. An endophytic Trichderma species was isolated from the stems of the medicinal plant Centaurea stoebe for examination of its metabolic profile. Activity guided fractionation of the ethyl acetate extract of the fungal isolate was performed followed by chromatographic purification of the isolated compounds and their spectroscopic identification. The bioactive secondary metabolites α-viridin, β-Viridin and adenosyl 9a-D-arabinofuranoside were isolated from the strain extract. Bioactive secondary metabolites have been isolated from an endophyte of the medicinal plant Centaurea stoebe and exhibit antifungal activity as well as potent cytotoxic and antiproliferative effects against HUVEC, K-562 and HeLa cancer cell lines.

Keywords: endophytes, Centaurea stoebe, antimicrobial, anticancer.